![]() "Prediction of the coding sequences of unidentified human genes. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". "Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis". Passani LA, Bedford MT, Faber PW, et al."Huntingtin interacts with a family of WW domain proteins". Faber PW, Barnes GT, Srinidhi J, et al.^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (September 1998)."The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters". ^ Al Sarakbi W, Sasi W, Jiang WG, Roberts T, Newbold RF, Mokbel K (2009)."SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability". ^ Pfister SX, Ahrabi S, Zalmas LP, Sarkar S, Aymard F, Bachrati CZ, Helleday T, Legube G, La Thangue NB, Porter AC, Humphrey TC (June 2014).^ a b c "Entrez Gene: SETD2 SET domain containing 2"."Identification of the full-length huntingtin- interacting protein p231HBP/HYPB as a DNA-binding factor". ^ Rega S, Stiewe T, Chang DI, Pollmeier B, Esche H, Bardenheuer W, Marquitan G, Putzer BM (Jul 2001)."Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase". ^ Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z (Oct 2005).National Center for Biotechnology Information, U.S. SETD2 belongs to a class of huntingtin interacting proteins characterized by WW motifs. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SETD2 has been shown to interact with Huntingtin. The SETD2 gene is located on the short arm of chromosome 3 and has been shown to play a tumour suppressor role in human cancer. Depletion of SETD2 increases the frequency of deletion mutations that arise by the alternative DNA repair process of microhomology-mediated end joining. The trimethylation of lysine-36 of histone H3 ( H3K36me3) is required in human cells for homologous recombinational repair and genome stability. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. SETD2 protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. SET domain containing 2 is an enzyme that in humans is encoded by the SETD2 gene. cellular response to DNA damage stimulus.regulation of protein localization to chromatin.microtubule cytoskeleton organization involved in mitosis.positive regulation of interferon-alpha production.regulation of double-strand break repair via homologous recombination.embryonic cranial skeleton morphogenesis.cell migration involved in vasculogenesis.transcription elongation from RNA polymerase II promoter.regulation of transcription, DNA-templated.Featuring a detachable sharpener and retractable tip, the formula is not only resistant to smudging but water, humidity, and oil too. Think of Chanel’s waterproof liner as a luxe staple worthy of your makeup bag, whether you’re a makeup pro or novice. The TikTok Viral: Rare Beauty Perfect Strokes Matte Liquid Liner, $21Ĭhanel Stylo Yeux Waterproof Long-Lasting Eyeliner.The Cult-Favorite: Urban Decay 24/7 Glide On Eye Pencil, $25.The Stay-All-Day: Make Up For Ever Aqua Resist Color Pencil Eyeliner, $24.The Creamy Satin: Victoria Beckham Beauty Satin Kajal Liner, $30.The Everyday Kohl: Jillian Dempsey Natural Khôl Eyeliner, $20.The Makeup Bag Staple: Chanel Stylo Yeux Waterproof Long-Lasting Eyeliner, $34.To help you in your hunt for the best eyeliner, we’ve consulted celebrity makeup artists and our own makeup bags to curate this edit of the formulas we can’t live without. There are even certain shades known to awaken tired eyes when applied to the waterline. Whether you’re looking for a liquid liner to create the ultimate cat-eye, a splash of color to spice up your minimalist makeup look, or simply an everyday pencil to pair with your favorite mascara and eyelash curler, you want it to stay on all day but also come off easily at night, while being gentle on the delicate eye area. The search for the best eyeliner can sometimes feel never-ending.
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